Anti-CD86 (Dendritic Cells Maturation Marker), clone SPM600

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Cell membrane. Positive Control: 293T or Jukat cells. Monocytes and dendritic cells, activated T, B and natural killer cells in lymph node or tonsil. Chromosome Location: 3q13.33. Protein Function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4 (PubMed:12196291). May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity) , Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation , (Microbial infection) Acts as a receptor for adenovirus subgroup B [The Uniprot Consortium]