Anti-CD74, clone YN00426m

CD74 is a membrane binding subunit of the class II related invariant chain of the major histocompatibility complex. CD74 is mainly used to label lymphocytes in germinal center and in the mantle cell area of lymph nodes. This does not label plasma cells or thymocytes, but usually labels dendritic cells. About 90% of low-grade B-cell lymphoma and 20% of low-grade T-cell lymphoma are expressing CD74, but in high-grade lymphoma, the ability to distinguish B cells from T cells is decreased. Protein function: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. [The UniProt Consortium]