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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10011432-25 | 25 µg | - |
6 - 10 business days* |
158.00€
|
|||
Cay10011432-100 | 100 µg | - |
6 - 10 business days* |
526.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD74 is a non-polymorphic type II integral membrane protein. It has a short N-terminal... more
Product information "Anti-CD74 (Clone PIN1)"
CD74 is a non-polymorphic type II integral membrane protein. It has a short N-terminal cytoplasmic tail of 28 amino acids, followed by a single 24 amino acid transmembrane region and an approximately 150 amino acid lumenal domain. The CD74 chain is thought to function mainly as a major histocompatibility complex (MHC) class II chaperone, which promotes endoplasmic reticulum (ER) exit of MHC class II molecules, directs them to endocytic compartments, prevents peptide binding in the ER, and contributes to peptide editing in the MHC class II compartment. Class II MHC and invariant chain expression was believed to be restricted to classical antigen-presenting cells (APC), however, during inflammation, other cell types, including mucosal epithelial cells, have also been reported to express class II MHC molecules. Experiments that investigate cell-surface CD74 are complicated by the fact that CD74 remains on the cell surface for a very short time. The surface half-life of CD74 was calculated to be fewer than 10 minutes. CD74 however has also recently been shown to have a role as an accessory-signalling molecule because of its macrophage migration-inhibitory factor (MIF). The restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases. Cayman's CD74 Monoclonal Antibody (Clone PIN1) can be used for flow cytometry (FC), immunohistochemistry (IHC), immunocytochemistry (ICC), immunofluorescence (IF), immunoprecipitation (IP), and Western blot (WB) applications.Formula Weight: 33.0. Immunogen: Human CD74 invariant chain synthetic peptide. Clone Designation: PIN.1. Formulation: (Request formulation change), 25 or 100 µg of protein G-affinity purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.09% sodium azide. Host: Mouse. Isotype: IgG1. Applications: FC, IHC, ICC, IF, IP, WB. Cross Reactivity: (+) Human CD74. Origin: Animal/Mouse.
Keywords: | Anti-Ii, Anti-p33, Anti-CD74, Anti-DHLAG, Anti-Ia antigen-associated invariant chain, Anti-HLA-DR antigens-associated invariant chain, Anti-HLA class II histocompatibility antigen gamma chain |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10011432 |
Properties
Application: | WB, IP, ICC, FC |
Antibody Type: | Monoclonal |
Clone: | PIN1 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | purified recombinant CD74 protein |
MW: | 33 D |
Format: | Solution |
Database Information
KEGG ID : | K06505 | Matching products |
UniProt ID : | P04233 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H316, H319 |
P Phrases: | P264, P280, P305+351+338, P332+313, P337+313 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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