Anti-CD66b (human), clone ANC1D5 (preservative free)

Monoclonal Antibody. Binds to CD66b on the cell surface of human PMN in flow cytometry and detects recombinant human CD66b in sandwich EIA utilizing either clone ANC4A4(Cat #ANC-220-020) or ANC3C5(Cat# ANC-219-020) as a capture reagent. May cross-react with other CD66 isoforms, as it also binds to the cell surface of an epithelial tumor line. Applications: ELISA, FACS. Isotype: Mouse IgG1kappa. Clone: ANC1D5. Liquid. 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl. Human CD66b (CEACAM8, CGMb, NCA-95, CD67) is a 95kD member of the Carcinoembryonic Antigen (CEA) group. It is expressed on granulocytes and functions as an adhesion molecule. Similar to the CD66 a, c, and d isoforms, engagement of CD66b on neutrophils causes increased adhesion to endothelial cells. Crosslinking CD66b on neutrophils with antibodies triggers IL-8 release.