Anti-CD63 (LAMP3), clone LAMP3/529

Anti-CD63 (LAMP3), clone LAMP3/529
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3028-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V3028-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This mAb recognizes protein of... more
Product information "Anti-CD63 (LAMP3), clone LAMP3/529"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This mAb recognizes protein of 26kDa-60kDa, which is identified as CD63/LAMP3. Its epitope is different from that of mAb LAMP3/803 or LAMP3/968 or NKI/C3 or MX-49.129.5. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63/LAMP3 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. It is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression. Protein function: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. [The UniProt Consortium]
Keywords: Anti-CD63, Anti-MLA1, Anti-LAMP-3, Anti-OMA81H, Anti-Tspan-30, Anti-CD63 antigen, Anti-Granulophysin, Anti-Tetraspanin-30, Anti-Melanoma-associated antigen ME491, Anti-Ocular melanoma-associated antigen, Anti-Lysosomal-associated membrane protein 3, CD63
Supplier: NSJ Bioreagents
Supplier-Nr: V3028-20UG

Properties

Application: FC, IF
Antibody Type: Monoclonal
Clone: LAMP3/529
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Recombinant human CD63 protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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