Anti-CD45 (Leukocyte marker), clone PTPRC/1460

Anti-CD45 (Leukocyte marker), clone PTPRC/1460
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3290SAF-100UG 100 µg - -

3 - 10 business days

1 mg/ml in 1X PBS, BSA free, sodium azide free. CD45R, also designated CD45 and PTPRC, has been... more
Product information "Anti-CD45 (Leukocyte marker), clone PTPRC/1460"
1 mg/ml in 1X PBS, BSA free, sodium azide free. CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. Protein function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. [The UniProt Consortium]
Keywords: Anti-CD45, Anti-L-CA, Anti-T200, Anti-PTPRC, EC=, Anti-Leukocyte common antigen, Anti-Receptor-type tyrosine-protein phosphatase C, CD45 Antibody (Leukocyte marker)
Supplier: NSJ Bioreagents
Supplier-Nr: V3290SAF-100UG


Application: FC, IHC (paraffin), IF
Antibody Type: Monoclonal
Clone: PTPRC/1460
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Human B lymphocytes were used as the immunogen for the CD45 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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