Anti-CD40 / CD40 molecule, clone r11E9

1 mg/ml in 1X PBS, BSA free, sodium azide free. CD40 molecule antibody recognizes CD40 molecule, also known as Tumor necrosis factor receptor superfamily member 5 antibody and TNFRSF5 antibody, a type I transmembrane receptor belonging to the tumor necrosis factor receptor superfamily. CD40 is expressed on the surface of B lymphocytes, dendritic cells, macrophages, and other antigen-presenting cells, where it plays a central role in regulating adaptive immune responses. CD40 Molecule Antibody , Clone r11E9 targets this immunoregulatory receptor for research applications investigating immune activation and lymphoid tissue biology.CD40 signaling is essential for T cell-dependent humoral immunity. Engagement of CD40 by its ligand CD154, also referred to as CD40 ligand or CD40L, expressed on activated CD4-positive T cells, leads to receptor trimerization and recruitment of TNF receptor-associated factors. This activates downstream pathways including NF-kappaB, MAPK, and PI3K, resulting in B cell proliferation, immunoglobulin class-switch recombination, germinal center formation, and memory B cell differentiation. In dendritic cells and macrophages, CD40 stimulation enhances antigen presentation and cytokine secretion, strengthening T cell priming and immune coordination.CD40 antibody research has been instrumental in understanding immune regulation, chronic inflammation, and tumor immunology. CD40 expression is prominent in reactive lymphoid tissues and in multiple B cell malignancies such as diffuse large B cell lymphoma, follicular lymphoma, and chronic lymphocytic leukemia. In addition to hematopoietic cells, CD40 expression can be induced in endothelial and epithelial cells during inflammatory conditions, linking CD40 signaling to autoimmune disorders and vascular inflammation.The CD40 protein contains extracellular cysteine-rich domains responsible for ligand binding and a cytoplasmic tail that mediates signaling through adaptor protein recruitment rather than intrinsic kinase activity. The CD40 gene is located on chromosome 20q13.12, and its expression is tightly regulated throughout B cell maturation and immune activation. Dysregulated CD40 signaling contributes to pathological immune activation and has been explored as a therapeutic target in both autoimmune disease and cancer immunotherapy.Clone r11E9 is a recombinant mouse monoclonal antibody that recognizes CD40 and supports detection of CD40 expression in research models. By targeting CD40 with high specificity, this antibody facilitates studies of B cell activation, antigen-presenting cell function, and CD40-mediated signaling pathways.