Anti-CD38, clone YN00346m

CD38 is a type II transmembrane glycoprotein, which is expressed in thymocytes, pre-T and B cells, activated T and B cells, plasma cells, monocytes, most NK cells, etc. It can be used to study the classification of acute leukemia and the role of activated T cells in autoimmunity and immune deficiency. Protein function: Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:8253715, PubMed:7961800). Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+) (PubMed:16690024). Has cADPR hydrolase activity (PubMed:8253715, PubMed:7961800). [The UniProt Consortium]