Anti-CD36, clone 1A7

Anti-CD36, clone 1A7
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3003SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes a protein of 80kDa-90kDa,... more
Product information "Anti-CD36, clone 1A7"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes a protein of 80kDa-90kDa, identified as CD36. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36. Protein function: Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. [The UniProt Consortium]
Keywords: Anti-FAT, Anti-GP3B, Anti-GPIV, Anti-CD36, Anti-PAS-4, Anti-GPIIIB, Anti-PAS IV, Anti-Glycoprotein IIIb, Anti-Fatty acid translocase, Anti-Thrombospondin receptor, Anti-Platelet glycoprotein 4, Anti-Platelet glycoprotein IV, CD36 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3003SAF-100UG

Properties

Application: FA (activity), FC, IF
Antibody Type: Monoclonal
Clone: 1A7
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Human CD36 derived from platelets
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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