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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V8765SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in 1X PBS, BSA free, sodium azide free. CD35, complement receptor 1, is a cell... more
Product information "Anti-CD35 / CR1, clone CR1/4382R"
1 mg/ml in 1X PBS, BSA free, sodium azide free. CD35, complement receptor 1, is a cell membrane-bound, monomeric glycoprotein on numerous cell types including erythrocytes, leukocytes, glomerular podocytes, and follicular dendritic cells. The primary function of CD35 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. CD35 antigen is found on erythrocytes, B cells, a subset of T cells, monocytes, as well as eosinophils, and neutrophils. Anti-CD35 is considered a mature B-cell marker which labels follicular dendritic reticulum cells and tumors derived from such cells such as follicular dendritic cell tumor/sarcoma. Protein function: Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728). [The UniProt Consortium]
Keywords: | Anti-CR1, Anti-CD35, Anti-C3BR, Anti-C3b/C4b receptor, Anti-Complement receptor type 1, CD35 Antibody / CR1 |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V8765SAF |
Properties
Application: | IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | CR1/4382R |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A portion of amino acids 1939-2039 from the human protein |
Format: | Purified |
Database Information
KEGG ID : | K04011 | Matching products |
UniProt ID : | P17927 | Matching products |
Gene ID | GeneID 1378 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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