Anti-CD35, clone E11

1 mg/ml in sterile PBS, BSA free, sodium azide free. This antibody recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1) / CD35. The antibody is specific for a site on CD35 that is distal from the C3b-binding site, so that it is unable to block CD35 activity. The CD35 / CR1 antibody is highly specific and shows no cross-reaction with CR2. The primary function of CD35 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This antibody labels follicular dendritic cells and follicular dendritic cell sarcoma. Protein function: Mediates cellular binding of particles and immune complexes that have activated complement. [The UniProt Consortium]