Anti-CD34, clone HPCA1/1171

Anti-CD34, clone HPCA1/1171
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3000SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. The CD34 protein is a member of a family of... more
Product information "Anti-CD34, clone HPCA1/1171"
1 mg/ml in sterile PBS, BSA free, sodium azide free. The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue. However, little is known about its exact function. CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia, whereas the L-selectin to which it binds is on the T cell. Conversely, under other circumstances CD34 has been shown to act as molecular Teflon and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumens. Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. Regardless of its mode of action, under all circumstances CD34, and its relatives podocalyxin and endoglycan, facilitates cell migration. [Wiki] Protein function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. [The UniProt Consortium]
Keywords: Anti-CD34, Anti-Hematopoietic progenitor cell antigen CD34, CD34 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3000SAF-100UG

Properties

Application: FC, IF, WB, IHC (paraffin)
Antibody Type: Monoclonal
Clone: HPCA1/1171
Conjugate: No
Host: Mouse
Reactivity: Human, Rat
Immunogen: Recombinant full-length human HPCA1 protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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