Anti-CD31 / PECAM-1

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a transmembrane glycoprotein that is found on the surface of various cell types, including platelets, endothelial cells, and leukocytes. One of the key roles of CD31 is its involvement in leukocyte trafficking and adhesion. Studies have shown that CD31 plays a crucial role in regulating the migration of immune cells to sites of inflammation or infection. By interacting with other proteins on the surface of immune cells, CD31 helps to mediate the adhesion and transmigration of these cells across the endothelium, allowing them to reach their target tissues and carry out their immune functions. CD31 has also been shown to regulate other important immune responses. For example, CD31 has been implicated in the modulation of T cell activation and proliferation. By interacting with other signaling molecules, CD31 can influence the signaling pathways that control T cell activation, ultimately shaping the immune response to pathogens or foreign antigens. Additionally, CD31 plays a role in the maintenance of vascular integrity. By promoting interactions between endothelial cells, CD31 helps to maintain the tight junctions that form the blood-brain barrier and other vascular structures. This function of CD31 is crucial for preventing the entry of pathogens and toxins into the bloodstream, protecting the body from potential harm.