Anti-CD27 / CD27 molecule, clone r137B4

0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide. CD27 antibody recognizes CD27 molecule, a type I transmembrane glycoprotein and member of the tumor necrosis factor receptor superfamily encoded by the CD27 gene. CD27 is primarily localized to the plasma membrane of T lymphocytes, memory B cells, and subsets of natural killer cells, where it functions as a co-stimulatory receptor that enhances lymphocyte activation, proliferation, and survival. CD27 Molecule Antibody is developed to support research into adaptive immunity, immune activation, and lymphocyte differentiation.The CD27 gene is located on chromosome 12p13 and encodes a protein containing extracellular cysteine-rich domains characteristic of TNF receptor family members, a single transmembrane segment, and a cytoplasmic tail that interacts with TRAF adaptor proteins. Binding of CD27 to its ligand CD70 activates downstream signaling pathways including NF-kappaB, promoting T-cell expansion, memory formation, and B-cell maturation. CD27 expression is tightly regulated during immune responses and is widely used as a marker to distinguish naive and memory lymphocyte subsets.In secondary lymphoid tissues such as tonsil and lymph node, CD27-positive cells are commonly observed within T-cell rich paracortical regions and among subsets of B cells associated with germinal center reactions. CD27 is broadly expressed on naive and central memory T cells and on memory B cells, whereas terminally differentiated effector cells may exhibit reduced expression. Dysregulated CD27 signaling has been associated with chronic infection, autoimmune disorders, and certain lymphoid malignancies. CD27 Molecule Antibody enables evaluation of CD27 distribution and expression levels in both normal and pathological immune contexts.The CD27-CD70 axis is actively investigated in immuno-oncology, as modulation of co-stimulatory signaling can enhance anti-tumor immune responses. Assessment of CD27 expression in tumor-infiltrating lymphocytes provides insight into immune activation status and microenvironment composition. Clone r137B4 is engineered as a recombinant mouse monoclonal antibody to provide consistent specificity and reproducibility in CD27 detection.By targeting a central regulator of lymphocyte activation, CD27 Molecule Antibody serves as a dependable reagent for studies of T-cell and B-cell biology, immune regulation, and translational immunotherapy research.This antibody is part of a broader CD27 antibody collection designed to support diverse immunological research applications.