Anti-CD23/FcepsilonRII (Capture/Detector)

CD23,also known as low affinity immunoglobulin epsilon Fc receptor,is a transmembrane glycoprotein present on a subpopulation of B lymphocytes in germinal centres,EBV-transformed B-lymphoblastoid cell lines,follicular dendritic cells,and a subpopulation of peripheral blood cells. CD23 has essential roles in the regulation of IgE production and in the differentiation of B-cells. Protein function: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells (PubMed:2167225). On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine- nitric oxide pathway (PubMed:7544003). [The UniProt Consortium]