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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V2985-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V2985-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of... more
Product information "Anti-CD22, clone MYG13"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of 130-140kDa, identified as CD22 (also known as BL-CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. Protein function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. [The UniProt Consortium]
Keywords: | Anti-CD22, Anti-BL-CAM, Anti-SIGLEC2, Anti-Siglec-2, Anti-B-cell receptor CD22, Anti-T-cell surface antigen Leu-14, Anti-B-lymphocyte cell adhesion molecule, Anti-Sialic acid-binding Ig-like lectin 2, CD22 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V2985 |
Properties
Application: | FA (activity), FC, IF |
Antibody Type: | Monoclonal |
Clone: | MYG13 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, mouse, rat (Expected: broad) |
Immunogen: | Raji cells |
Format: | Purified |
Database Information
KEGG ID : | K06467 | Matching products |
UniProt ID : | P20273 | Matching products |
Gene ID | GeneID 933 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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