Anti-CD200/OX2 (mouse), clone OX-90, FITC conjugated

Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. CD200 (OX-2 antigen) is a type-1 membrane glycoprotein containing two extracellular Ig-like domains. CD200 a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types including thymocytes, some T cells, endothelial and follicular dendritc cells,?B cells,?and brain tissue (neurons), but not on NK cells, granulocytes, monocytes, or macrophages.? CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues.? CD200 is the ligand for CD200 receptor (CD200R).? The CD200 Receptor is restricted to myeloid cells, and it is believed that its engagement with CD200 results in inhibition and/or downregulation of myeloid cell activity.? Blocking of CD200/CD200R interactions decreases myeloid cell inhibitory thresholds which results in enhanced immune activation. Protein function: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. [The UniProt Consortium]