Anti-CD20 (C-Term) Rabbit Monoclonal Antibody (Clone RM272)

CD20 is a non-glycosylated protein encoded by MS4A1 in humans. It is comprised of four transmembrane domains, a single intracellular loop, and two extracellular loop domains with both the N- and C-termini located in the cytosol. CD20 is a general B cell marker that is expressed from the late pre-B lymphocyte stage but is not expressed by pro-B lymphocytes and is lost in terminally differentiated plasma cells and plasmablasts. It forms supramolecular complexes with CD53, CD81, and CD82, as well as MHCII, CD40, B cell receptors, and C-terminal Src kinase-binding protein (CBP) to contribute to signal transduction. MS4A1 expression is variable in B cell malignancies, with the lowest expression found in patients with chronic lymphocytic leukemia (CLL) and the highest expression found in patients with diffuse large B cell lymphoma (DLBCL) or hairy cell lymphomas. MS4A1 expression is enriched on IFN-gamma-inducible T-box transcription factor-expressing B cells in blood isolated from patients with multiple sclerosis. Cayman's CD20 (C-Term) Rabbit Monoclonal Antibody (Clone RM272) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: B-lymphocyte Cell-surface Antigen B1, Membrane-spanning 4-domains Subfamily A Member 1. Immunogen: Peptide from the C-terminal region of human CD20. Clone Designation: RM272. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) CD20.