Anti-CD18 / LFA-1 beta, clone YFC118.3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG23054.100	100 µg		-	-	6 - 14 business days*		640.00€

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Protein function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4.... more

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Product information "Anti-CD18 / LFA-1 beta, clone YFC118.3"

Protein function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). [The UniProt Consortium]

Keywords:	Anti-CD18, Anti-ITGB2, Anti-Integrin beta-2, Anti-Complement receptor C3 subunit beta, Anti-Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG23054

Properties

Application:	IHC (frozen), FC, IP
Antibody Type:	Monoclonal
Clone:	YFC118.3
Conjugate:	No
Host:	Rat
Species reactivity:	human, dog, guinea pig
Immunogen:	Human neutrophils
Format:	Purified