Anti-CD161, clone B199.2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG22963.100	100 µg		-	-	6 - 14 business days*		640.00€

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Protein function: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation... more

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Product information "Anti-CD161, clone B199.2"

Protein function: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. [The UniProt Consortium]

Keywords:	Anti-CD161, Anti-KLRB1, Anti-CLEC5B, Anti-NKR-P1A, Anti-HNKR-P1a, Anti-C-type lectin domain family 5 member B, Anti-Natural killer cell surface protein P1A, Anti-Killer cell lectin-like receptor subfamily B member 1
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG22963

Properties

Application:	IHC (frozen), FC, IP
Antibody Type:	Monoclonal
Clone:	B199.2
Conjugate:	No
Host:	Mouse
Species reactivity:	human
Immunogen:	Purified Human NK cells cultured in IL-2 (Bennett et al. 1996)
Format:	Purified