Anti-CD16, clone 2B1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-22048.20 20 µl -

7 - 16 business days*

72.00€
E-AB-22048.60 60 µl -

7 - 16 business days*

142.00€
E-AB-22048.120 120 µl -

7 - 16 business days*

238.00€
E-AB-22048.200 200 µl -

7 - 16 business days*

395.00€
 
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the... more
Product information "Anti-CD16, clone 2B1"
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Protein function: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (PubMed:24412922, PubMed:25786175, PubMed:21768335, PubMed:22023369, PubMed:8609432, PubMed:9242542, PubMed:25816339, PubMed:11711607, PubMed:28652325). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation. Involved in the generation of memory- like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC (PubMed:25786175, PubMed:24412922). Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (PubMed:9916693, PubMed:29967280). Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation. The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation (PubMed:2532305, PubMed:1825220, PubMed:23024279). Costimulates NK cells and trigger lysis of target cells independently of IgG binding (PubMed:23006327, PubMed:10318937). Mediates the antitumor activities of therapeutic antibodies. Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells (PubMed:27670158). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821). [The UniProt Consortium]
Keywords: Anti-CD16a, Anti-FcR-10, Anti-FcRIII, Anti-CD16-II, Anti-FcRIIIa, Anti-FcgammaRIIIA, Anti-CD16a antigen, Anti-Fc-gamma RIII, Anti-Fc-gamma RIIIa, Anti-Fc-gamma RIII-alpha, Anti-IgG Fc receptor III-2, Anti-IgG Fc receptor III-A, CD16 Monoclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-22048

Properties

Application: WB, IHC (paraffin)
Antibody Type: Monoclonal
Clone: 2B1
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Synthetic Peptide
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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