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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V2699SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in sterile PBS, BSA free, sodium azide free. The human Mel-CAM gene maps to chromosome... more
Product information "Anti-CD146 (MCAM), clone MUC18/1130"
1 mg/ml in sterile PBS, BSA free, sodium azide free. The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease. Protein function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. [The UniProt Consortium]
Keywords: | Anti-MCAM, Anti-CD146, Anti-MUC18, Anti-Cell surface glycoprotein P1H12, Anti-Melanoma cell adhesion molecule, Anti-Cell surface glycoprotein MUC18, Anti-Melanoma-associated antigen A32, Anti-Melanoma-associated antigen MUC18, CD146 Antibody (MCAM) |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V2699SAF |
Properties
Application: | FC, IF, IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | MUC18/1130 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant human CD146/MUC18 protein |
Format: | Purified |
Database Information
KEGG ID : | K06534 | Matching products |
UniProt ID : | P43121 | Matching products |
Gene ID | GeneID 4162 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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