Anti-CD146, clone RM249 (recombinant antibody)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
NSJ-R20269-0.1ML	100 µl		-	-	3 - 10 business days*		772.00€

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Antibody in PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide. This recombinant CD146 antibody... more

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Product information "Anti-CD146, clone RM249 (recombinant antibody)"

Antibody in PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide. This recombinant CD146 antibody reacts to human CD146 (Cell surface glycoprotein MUC18). It may also react to the mouse and rat protein, as predicted by immunogen homology. Protein function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. [The UniProt Consortium]

Keywords:	Anti-MCAM, Anti-CD146, Anti-MUC18, Anti-Cell surface glycoprotein MUC18, Anti-Cell surface glycoprotein P1H12, Anti-Melanoma-associated antigen A32, Anti-Melanoma cell adhesion molecule, Anti-Melanoma-associated antigen MUC18, Recombinant CD146 Antibody
Supplier:	NSJ Bioreagents
Supplier-Nr:	R20269

Properties

Application:	WB, IHC
Antibody Type:	Monoclonal
Clone:	RM249
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	A peptide corresponding to the residues near C-terminus of human CD146 was used as the immunogen for this recombinant CD146 antibody.
Format:	Purified