Anti-CD133 (human), mAb (ANC9C5) (Biotin)

Human CD133 is a 117kd pentaspan transmembrane glycoprotein expressed by a subset of hematopoetic and other types of stem cells found in blood and a variety of tissues. Increased expression of CD133 may be a predictor of decreased prognosis in patients with metastatic cancer. Antibody ANC9C5 recognizes epitope 1 of human CD133(AC133) present on full length CD133 transfectants, Y79 retinoblastoma and other cell types. Antibody ANC9C5 has been used to image cancer stem cells in a colon carcinoma xenograft. Protein function: May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol- containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439). [The UniProt Consortium]