Anti-CD13

CD13/aminopeptidase N is a 150 kDa cell surface glycoprotein,which was originally used as a marker for subpopulations of hematopoietic cells. CD13 is widely distributed in a variety of mammalian cells,such as monocyte/macrophages,fibroblasts,neutrophils,endothelial cells,and epithelial cells. CD13 is also a pan-myeloid marker,present on mature granulocytes and monocytes. Protein function: Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells (PubMed:8691132). May have a role in angiogenesis and promote cholesterol crystallization. [The UniProt Consortium]