Anti-CD126 (human), Unconjugated Clone B-R6 [Mouse]

Specificity: Recognises the Interleukin-6 Ra subunit, IL-6 Ra, IL-6 R, a 80 kDa protein, Format: Phosphate-buffered saline with 1 % BSA and 0.1 % sodium azide, Working Dilution: Use 10 µl to label 106 cells or 100 µl of whole blood, Storage: Stable at +2-8°C for 12 months For longer storage, freeze aliquots, Application Notes: Suitable for Flow Cytometry, IHC frozen sections, Recognises Bound and soluble CD126 Protein function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis (Probable). The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). [The UniProt Consortium]