Anti-CD11b / MAC-1 (C-Terminal) (recombinant antibody), clone RM290

Antibody in PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide. This antibody reacts to human CD11b (MAC-1, Integrin alpha-M, ITGAM). Protein function: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. [The UniProt Consortium]