Anti-CD105 / Endoglin, clone r4G11

1 mg/ml in 1X PBS, BSA free, sodium azide free. ENG antibody targets Endoglin, a homodimeric transmembrane glycoprotein encoded by the ENG gene and widely known as CD105. Endoglin is predominantly localized to the cell surface of endothelial cells, where it functions as an auxiliary receptor within the transforming growth factor beta signaling pathway. ENG expression is particularly high in proliferating and activated endothelial cells, reflecting its important role in vascular development, angiogenesis, and endothelial cell function. Endoglin antibody reagents are therefore commonly used in studies of vascular biology and tumor associated angiogenesis.Functionally, Endoglin modulates signaling mediated by transforming growth factor beta family ligands by interacting with type I and type II receptors, influencing downstream SMAD-dependent pathways. A short functional summary is that ENG regulates endothelial cell proliferation, migration, and vascular remodeling during both physiological and pathological angiogenesis. Through this regulatory role, CD105 contributes to maintenance of vascular integrity and adaptive responses to hypoxia and tissue injury.At the molecular level, Endoglin contains a large extracellular domain involved in ligand and receptor interactions, a single transmembrane region, and a short cytoplasmic tail that participates in intracellular signaling. ENG exists primarily as a disulfide linked homodimer at the cell surface. Clone r4G11 recombinant antibody is designed to recognize Endoglin and supports consistent detection of ENG expression in endothelial cells and vascular rich tissues in research settings.From a biological and disease relevance perspective, ENG expression is strongly associated with neovascularization in solid tumors, inflammatory conditions, and wound healing. Endoglin is frequently used as a marker of tumor associated vasculature and microvessel density in cancer research. Genetic alterations in ENG are also linked to hereditary hemorrhagic telangiectasia, underscoring its critical role in vascular homeostasis. Clone r4G11 provides a reliable tool for investigating Endoglin expression in studies of angiogenesis, vascular pathology, and endothelial cell biology.Developmentally, ENG is essential for normal vascular formation and endothelial cell differentiation. Its expression increases in response to angiogenic stimuli and endothelial activation. ENG antibodies from NSJ Bioreagents are supplied for research use to support investigations in angiogenesis, cancer biology, and vascular signaling. For broader detection of CD105 as an endothelial marker across applications, see our CD105 antibody.