Anti-CD105 (Endoglin, gp160, TGF beta1,3 Receptor, HHT1, ORW1, Osler Rendu Weber syndrome 1)

Anti-CD105 (Endoglin, gp160, TGF beta1,3 Receptor, HHT1, ORW1, Osler Rendu Weber syndrome 1)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C2446-50E5.100 100 µl - -

3 - 19 business days*

682.00€
 
Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-Beta receptor complex, functioning in... more
Product information "Anti-CD105 (Endoglin, gp160, TGF beta1,3 Receptor, HHT1, ORW1, Osler Rendu Weber syndrome 1)"
Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-Beta receptor complex, functioning in related signaling pathways (1,2). Endoglin is a transmem-brane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos (1-4). Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer (4-6). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight. , Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-ENG
Supplier: United States Biological
Supplier-Nr: C2446-50E5

Properties

Application: WB
Antibody Type: Monoclonal
Clone: 10E14(D50G1)
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Synthetic peptide corresponding to residues surrounding Ala463 of human endoglin protein (KLH).
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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