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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V2462SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in sterile PBS, BSA free, sodium azide free. Reacts with the N-terminal extracellular... more
Product information "Anti-CCR5, clone 12D1"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer. Protein function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. [The UniProt Consortium]
Keywords: | Anti-CCR5, Anti-CCR-5, Anti-CD195, Anti-CMKBR5, Anti-CHEMR13, Anti-CC-CKR-5, Anti-C-C CKR-5, Anti-HIV-1 fusion coreceptor, Anti-C-C chemokine receptor type 5, CCR5 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V2462SAF |
Properties
Application: | FC, IF, FA (activity), IF |
Antibody Type: | Monoclonal |
Clone: | 12D1 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Native human CCR5 protein |
Format: | Purified |
Database Information
KEGG ID : | K04180 | Matching products |
UniProt ID : | P51681 | Matching products |
Gene ID | GeneID 1234 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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