Anti-CCL2 (equine)

The Equine CCL2 (MCP-1) polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Equine CCL2 ELISA. The Equine CCL2 polyclonal antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine CCL2 - Strong) (Canine CCL2 - Strong) (Equine CCL2 - Strong) (Guinea Pig CCL2 - None) (Mouse CCL2 - Weak) (Rabbit CCL2 - None) (Swine CCL2 - Strong). For research use only. Made in the USA Protein function: Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. [The UniProt Consortium]