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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
200-401-B60 | 100 µg | - | - |
6 - 10 business days* |
684.00€
|
CCL2 is a small cytokine belonging to the CC chemokine family that recruits monocytes, memory T... more
Product information "Anti-CCL2"
CCL2 is a small cytokine belonging to the CC chemokine family that recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing a signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a total molecular weight of approximately 8.8 kDa. The cell surface receptors that bind CCL2 are CCR2 and CCR4. CCL2 is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor kappaB (NFkappaB). In human osteoclasts, CCL2 and RANTES (regulated on activation normal T cell expressed and secreted) may act as an autocrine loop in human osteoclast differentiation. CCL2 causes the degranulation of basophils and mast cells, an effect potentiated by pre-treatment with IL-3 and other cytokines.
Keywords: | Anti-CCL2, Anti-MCP-1, Anti-SCYA2, Anti-MCP-1A, Anti-C-C motif chemokine 2, Anti-Small-inducible cytokine A2, Anti-Acidic seminal fluid protein, Anti-Monocyte chemotactic protein 1A |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 200-401-B60 |
Properties
Application: | ELISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | bovine |
Immunogen: | recombinant protein raised in yeast, corresponding to the 76 amino acids of the mature bovine CCL2 protein |
MW: | 8.8 kD |
Format: | Purified |
Database Information
KEGG ID : | K14624 | Matching products |
UniProt ID : | P28291 | Matching products |
Gene ID | GeneID 281043 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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