Anti-Cbl

Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-AE8 100 µg - -

6 - 10 business days*

684.00€
 
Anti-Cbl Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-Cbl"
Anti-Cbl Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Cbl from other sources has not been determined. Protein function: Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. [The UniProt Consortium]
Keywords: Anti-CBL, Anti-CBL2, EC=6.3.2.-, Anti-Proto-oncogene c-Cbl, Anti-RING finger protein 55, Anti-E3 ubiquitin-protein ligase CBL, Anti-Signal transduction protein CBL, Anti-Casitas B-lineage lymphoma proto-oncogene
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-AE8

Properties

Application: ELISA, IFM, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: 14 amino acid synthetic peptide from near the C-terminus of human cbl.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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