Anti-CBFA2T2

Anti-CBFA2T2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-593A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-593A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-593A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Transcriptional corepressor which facilitates transcriptional repression via... more
Product information "Anti-CBFA2T2"
Protein function: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner. Can repress the expression of MMP7 in a ZBTB33- dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8,21). May thus be involved in the repression of AML1-dependent transcription and the induction of G- CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation. [The UniProt Consortium]
Keywords: Anti-EHT, Anti-p85, Anti-CBFA2T2, Anti-Protein CBFA2T2, Anti-MTG8-like protein, Anti-MTG8-related protein 1, Anti-ETO homologous on chromosome 20, Anti-Myeloid translocation-related protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: A303-593A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Chicken, Turkey, Bovine, Dog, Horse, Guinea Pig_10141, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, African Elephant, Naked Mole Rat, Small-eared Galago, Zebra Finch)
Immunogen: synthetic peptide. The epitope recognized by A303-593A-T maps to a region between residue 554 and 604 of human Core-Binding Factor, Runt Domain, Alpha Subunit 2, translocated to, 2 using the numbering given in entry NP_005084.1 (GeneID 9139).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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