Anti-CAV1

Caveolin-1 (CAV1),a multifunctional protein,is the main constituent molecule of caveolae and represents a scaffolding molecule for several signaling molecules including epidermal growth factor receptor . Several studies have implicated that a reduced expression of CAV1 was found in cancers including head and neck carcinoma . However,other studies recognize CAV1 as a tumor promoter because CAV1 is overexpressed in various kinds of cancers,especially in oral cancer . Recent study also show that CAV1 is involved in astric Cancer . Protein function: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). [The UniProt Consortium]