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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
REV-31-1130-00-R100 | 100 µl | - | - |
3 - 9 business days* |
483.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Recombinant Antibody. This antibody reacts to human full length caspase-3 (35 kDa) and the large... more
Product information "Anti-Caspase-3 (human), Rabbit Monoclonal (RM250)"
Recombinant Antibody. This antibody reacts to human full length caspase-3 (35 kDa) and the large fragment of caspase-3 resulting from cleavage (17 kDa). Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Caspase-3 is a member of the interleukin-1 beta-converting enzyme family. This cytoplasmic caspase functions as a heterotetramer and has two isoforms (one acts as a dominant negative inhibitor). The proform of this caspase is approximately 32 kD. Activation of caspase-3 requires proteolytic processing of its inactive pro-form into activated p17 and p12 fragments. Caspase-3 is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP). Caspase-3 is inhibited by c-IAP1, c-IAP2, XIAP, survivin and Livin and activated by Caspase-6, -8 , and -10, granzyme B, Apaf-1 by cleavage into large p17 and small p12 subunits. Caspase-3 has been shown to cleave PARP, huntingtin, androgen receptor, atrophin-1, DNA- PKcs, D4-GDI, hnRNPs C1/C2, U1snRNP, PKC delta, ATM, fodrin, gelsolin, ICAD, RIP, X-IAP, STAT1, topoisomerase I, vimentin, Rb, lamin B, mdm2, and beta-catenin. Caspase-3 is important for normal brain development as well as its typical role in apoptosis, where it is responsible for chromatin condensation and DNA fragmentation. Elevated levels of a fragment of Caspase-3, p17, in the bloodstream is a sign of a recent myocardial infarction. Caspase-3 may play a role in embryonic and hematopoietic stem cell differentiation.
Keywords: | CASP-3, Apopain, Cysteine Protease CPP32, SREBP Cleavage Activity 1, SCA-1 |
Supplier: | RevMAb Biosciences |
Supplier-Nr: | 31-1130-00 |
Properties
Application: | WB, IHC |
Antibody Type: | Monoclonal |
Clone: | RM250 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Format: | Purified |
Database Information
KEGG ID : | K02187 | Matching products |
UniProt ID : | P42574 | Matching products |
Gene ID | GeneID 836 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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