Anti-Caspase-14

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG55190.100	100 µl		-	-	6 - 14 business days*		707.00€

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Protein function: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant... more

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Product information "Anti-Caspase-14"

Protein function: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736). [The UniProt Consortium]

Keywords:	Anti-CASP14, EC=3.4.22.-
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG55190

Properties

Application:	WB, ICC, IF
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse
Immunogen:	Recombinant protein of Human Caspase-14 (NP_036246.1)
MW:	27 kD
Format:	Antigen Affinity Purified