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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ARG43383.100 | 100 µl | - | - |
6 - 14 business days* |
658.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant... more
Product information "Anti-Caspase 14"
Protein function: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736). {ECO:0000250, UniProtKB:O89094, ECO:0000269, PubMed:15301553, ECO:0000269, PubMed:15556625, ECO:0000269, PubMed:16854378, ECO:0000269, PubMed:19960512, ECO:0000269, PubMed:22825846, ECO:0000269, PubMed:24743736, ECO:0000305, PubMed:25121097}. [The UniProt Consortium]
| Keywords: | Anti-CASP14, Anti-CASP-14, Anti-Caspase-14, Anti-Caspase-14 subunit p17, mature form, Anti-Caspase-14 subunit p10, mature form, Anti-Caspase-14 subunit p8, intermediate form, Anti-Caspase-14 subunit p20, intermediate form |
| Supplier: | Arigo Biolaboratories |
| Supplier-Nr: | ARG43383 |
Properties
| Application: | FC, ICC, IF, IHC (paraffin), IP, WB |
| Antibody Type: | Polyclonal |
| Conjugate: | No |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
| Immunogen: | Synthetic peptide derived from Human Caspase 14 |
| MW: | 28 kD |
| Format: | Affinity Purified |
Database Information
| KEGG ID : | K04401 | Matching products |
| UniProt ID : | P31944 | Matching products |
| Gene ID : | GeneID 23581 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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