Anti-Caspase-14

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-KC-3124.50	50 µl		-	-	10 - 15 business days*		206.00€
ABS-KC-3124.100	100 µl		-	-	10 - 15 business days*		295.00€

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Protein function: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant... more

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Product information "Anti-Caspase-14"

Protein function: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736). [The UniProt Consortium]

Keywords:	Anti-Caspase-14, Anti-CASP-14) [Cleaved into: Caspase-14 subunit p17, Anti-mature form, Anti-Caspase-14 subunit p10, Anti-mature form, Anti-Caspase-14 subunit p20, Anti-intermediate form, Anti-Caspase-14 subunit p8, Anti-intermediate form], CASP14 Antibod
Supplier:	Absea
Supplier-Nr:	KC-3124

Properties

Application:	IHC
Antibody Type:	Monoclonal
Clone:	7F2
Conjugate:	No
Host:	Mouse
Species reactivity:	human
Immunogen:	Recombinant human CASP14
Format:	Solution

Database Information

KEGG ID :	K04401 \| Matching products
UniProt ID :	P31944 \| Matching products
Gene ID :	GeneID 23581 \| Matching products

Handling & Safety

Storage:	-20°C (avoid repeat freezing and thawing cycles)
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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