Anti-Carcinoembryonic Antigen (CEA) / CD66, clone SPM584

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Apical cell membrane, Cell membrane, Cell surface. Positive Control: MCF7 or 293T cells. Colon carcinoma. Chromosome Location: 19q13.2. Protein Function: Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression. induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050) , (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer [The Uniprot Consortium]