Anti-Carbonic Anhydrase IX, clone 66.4.C2

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This antibody recognizes a glycoprotein of ~200kDa, identified as renal cell carcinoma protein, carbonic anhydrase IX (CAIX), or gp200. Its epitope resides in the carbohydrate domain of gp200. The carbonic anhydrase IX antibody shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, carbonic anhydrase IX is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, carbonic anhydrase IX is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This antibody may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation. Protein function: Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. [The UniProt Consortium]