Anti-CAMP (Cathelicidin Antimicrobial Peptide, 18kD Cationic Antimicrobial Protein, CAP-18, hCAP-18,

Anti-CAMP (Cathelicidin Antimicrobial Peptide, 18kD Cationic Antimicrobial Protein, CAP-18, hCAP-18,
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C7906-74C.100 100 µg - -

3 - 19 business days*

962.00€
 
CAMP (Cathelicidin AntiMicrobial Peptide? also18kD cationic antimicrobial protein, CAP18, LL37,... more
Product information "Anti-CAMP (Cathelicidin Antimicrobial Peptide, 18kD Cationic Antimicrobial Protein, CAP-18, hCAP-18,"
CAMP (Cathelicidin AntiMicrobial Peptide? also18kD cationic antimicrobial protein, CAP18, LL37, FALL39 and HSD26) is a member of the cathelicidin family of proteins. It is widely expressed, being found associated with neutrophils, bronchial epithelium, renal tubule epithelium, activated keratinocytes, gd T cells, monocytes, NK cells, colonic epithelium and the stratum basale of nonkeratinized epithelium found in the vagina and oral cavity. CAMP has marked antimicrobial activity against both Gm+ and Gm- bacteria, and acts as a chemoattractant for neutrophils, monocytes and mast cells. CAMP is synthesized as 170aa preproprecursor. It contains a 30aa signal sequence, a 103aa, 14kD prosegment (aa31-131) and a 4-5kD, 37aa (aa134-170) C-terminal mature fragment (LL37) or 39aa (aa132-170) C-terminal mature fragment (FALL39). In neutrophils, the 18-19kD proprecursor is stored in granules, where, upon activation, it is enzymatically cleaved and released. While both the prosegment and C-terminal fragments possess antimicrobial activity, the prosegment also shows protease activity, while the C-terminal fragment also shows chemotactic activity. The prosegment may form homodimers, while the C-terminal fragment (LL37) is reported to form homotetramers. Over aa141-170, human CAMP shares only 50% and 57% aa sequence identity with mouse and rat CAMP, respectively. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-CAMP, Anti-HSD26, Anti-CAP18
Supplier: United States Biological
Supplier-Nr: C7906-74C

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Sheep
Species reactivity: human
Immunogen: Recombinant corresponding to aa134-170 from human CAMP expressed in E.coli.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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