Anti-Calsequestrin 1 [R08-4A1] Monoclonal Antibody

Calsequestrin 1 Monoclonal Antibody from Assay Genie is a high quality antibody for research use only. Protein Function: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:28895244). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions (PubMed:28895244). Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1, this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (PubMed:27185316) [The Uniprot Consortium]