Anti-Calnexin (Endoplasmic Reticulum Marker), recombinant antibody, clone CANX/9147R

Formulation: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml. Cellular Localization: Cytoplasm. Positive Control: HeLa, MCF-7 or U2OS cells. Kidney or small intestine. Brain, Heart, Intestine, Kidney, Liver, Lung, Pancreas, Skin, Skeletal muscle and Stomach. Chromosome Location: 5q35.3. Protein Function: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse [The Uniprot Consortium]