Anti-CALD1 / Caldesmon 1, clone MSVA-538R

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Caldesmon (CALD1) is an actin- and myosin-binding regulatory protein that functions as a key marker of smooth muscle differentiation and cytoskeletal organization. Caldesmon Antibody for IHC / CALD1 Immunohistochemistry Antibody (clone MSVA-538R) is optimized for immunohistochemistry-based detection of CALD1 in formalin-fixed, paraffin-embedded tissues, where it produces distinct cytoplasmic staining of smooth muscle cells and highlights contractile filament structures within intact tissue architecture.Caldesmon Antibody for IHC / CALD1 Immunohistochemistry Antibody (clone MSVA-538R) has been evaluated across a wide range of human tissue microarray (TMA) samples, demonstrating consistent and reproducible staining across multiple normal and cancer tissue types. Caldesmon antibody, also referred to as CALD1 antibody or h-caldesmon antibody, shows strong cytoplasmic staining in vascular smooth muscle, myometrium, gastrointestinal muscularis layers, and myoepithelial cells. In IHC staining applications, this pattern is characterized by elongated, spindle-shaped cells with filamentous cytoplasmic localization, supporting clear visualization of smooth muscle architecture in FFPE sections.This Caldesmon Antibody for IHC / CALD1 Immunohistochemistry Antibody is uniquely positioned as a TMA-validated reagent for tissue-based detection of smooth muscle differentiation, enabling reliable interpretation in histological and diagnostic research settings. The recombinant rabbit monoclonal clone MSVA-538R antibody provides uniform staining intensity and low non-specific background, supporting consistent performance across diverse FFPE tissue specimens. In cancer tissue microarrays, caldesmon staining is typically retained in smooth muscle-derived tumors such as leiomyomas and leiomyosarcomas, while epithelial and non-muscle tumors generally lack strong cytoplasmic staining, supporting its role in lineage identification.At the biological level, CALD1 expression is associated with differentiated smooth muscle phenotype and is coordinated with cytoskeletal remodeling and contractile function. High molecular weight caldesmon isoforms are enriched in mature smooth muscle cells and contribute to stable actin filament interactions, while lower molecular weight isoforms are less prominent in tissue-based IHC staining. Immunohistochemistry using Caldesmon Antibody for IHC (clone MSVA-538R) enables direct visualization of these expression patterns within preserved tissue morphology.Due to its strong performance in immunohistochemistry and extensive validation using human tissue microarrays, Caldesmon Antibody for IHC / CALD1 Immunohistochemistry Antibody (clone MSVA-538R) provides a reliable tool for detecting CALD1 expression in studies focused on tissue morphology, tumor classification, and smooth muscle biology. Its robust cytoplasmic staining pattern, clear smooth muscle specificity, and reproducibility across TMA datasets make it well suited for evaluating smooth muscle differentiation in both normal and pathological specimens.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.