Anti-Calcineurin B homologous protein 2 / HCC Antigen 520, clone CPTC-CHP2-1

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Cell membrane, Cytoplasm, Nucleus. Positive Control: K562 or Jurkat cell lysates. Human appendix or testis., MCF-7. Chromosome Location: 16p12.2. Protein Function: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus [The Uniprot Consortium]