Anti-C1QA / Complement component 1 subcomponent subunit A, clone 31C57

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. C1QA antibody detects complement component 1 subcomponent subunit A, encoded by the C1QA gene. C1QA is one of three chains (A, B, and C) that assemble to form the C1q protein complex, a recognition unit of the classical complement pathway. C1q binds to antibodies or immune complexes, initiating complement activation and promoting clearance of pathogens and apoptotic cells. Through these roles, C1QA is central to innate immunity and host defense.C1QA antibody is commonly used in immunology, inflammation, and autoimmune disease research. C1QA expression is highest in monocytes, macrophages, and dendritic cells. It functions as a pattern recognition receptor that bridges innate and adaptive immunity. By detecting C1QA, researchers can study activation of complement pathways and regulation of immune responses. In western blot assays, C1QA antibody detects protein bands of expected size in immune cell extracts. Immunohistochemistry highlights strong expression in macrophages and tissue resident immune cells. Immunofluorescence enables visualization of C1QA in immune synapses and complement activation sites. ELISA supports quantification of circulating C1QA in biological samples.Deficiency of C1QA is associated with autoimmune disorders such as systemic lupus erythematosus, underscoring its importance in self tolerance and immune clearance. Elevated expression of C1QA has been linked to chronic inflammation and neurodegenerative diseases, including Alzheimer disease, where complement activation contributes to pathology. By applying C1QA antibody, scientists can investigate how alterations in complement regulation affect health and disease.C1QA antibody from NSJ Bioreagents offers reliable specificity for complement research. Its performance across methods ensures accurate detection of this key immune recognition protein.