Anti-C10orf90

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA038648.25	25 µl		-		7 - 10 business days*		369.00€
ATA-HPA038648.100	100 µl		-		7 - 10 business days*		491.00€

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Protein function: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage.... more

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Product information "Anti-C10orf90"

Protein function: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys- 63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21. May have a role in the assembly of primary cilia (Probable). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 59% and to rat: 62%

Keywords:	Anti-FATS, Anti-Centrosomal protein C10orf90, Anti-E2/E3 hybrid ubiquitin-protein ligase FATS, Anti-Fragile-site associated tumor suppressor homolog, Anti-(E2-independent) E3 ubiquitin-conjugating enzyme FATS
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA038648

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: AEDTLFQAPP ALANGAHPGR HQRSFACTEF SRNSSVVRLK VPEAHTGLCE RRKYWVTHAD DKETSFSPDT PLSGKSPLVF SSCVHLRVSQ QCPD (ATA-APrEST80310)