Anti-c-Rel

Anti-c-Rel
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-826A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A301-826A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A301-826A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Proto-oncogene that may play a role in differentiation and lymphopoiesis.... more
Product information "Anti-c-Rel"
Protein function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. [The UniProt Consortium]
Keywords: Anti-REL, Anti-Proto-oncogene c-Rel
Supplier: Bethyl Laboratories
Supplier-Nr: A301-826A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Brown Woolly Monkey, Crab-eating Macaque, Pygmy Chimpanzee, Bornean Orangutan, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-826A-T maps to a region between residue 569 and 619 of human reticuloendotheliosis viral oncogene homolog using the numbering given in entry NP_002899.1 (GeneID 5966).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-c-Rel"
Write a review
or to review a product.
Viewed