Anti-c-Myc, mAb (rec.) (9E10 improved variant) (Fc Rabbit)

The c-Myc or myc-tag is widely used to detect expression of recombinant proteins in bacteria, yeast, insect and mammalian cell systems. Hyper-Myc is an improved engineered anti-c-myc tag antibody. It showed a higher affinity and stability in direct comparison to hybridoma antibody 9E10 (anti-c-myc-tag). This antibody can be detected with anti-rabbit Fc secondary antibodies. Protein function: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release. [The UniProt Consortium]